Moderna -mRNA1273

How Moderna and Pfizer’s vaccine will work

Yesterday Biotech firm Moderna declared that its Coronavirus vaccine is found to be over 94% efficacy rate. Moderna’s vaccine is in its phase-3 clinical trials. The results are from the initial samples of 95 volunteers. In phase-3 clinical trials, the Biotech firm is conducting tests on 30,000 volunteers from different parts of the world. Earlier in the week, Pfizer also claimed that its COVID-19 vaccine is over 90% efficacy rate.

How Coronavirus vaccine will work

Moderna’s vaccine mRNA-1273 and Pfizer’s vaccine BNT162b2 are developed using the same technology. Both developed vaccines using the RNA sequence of Coronavirus. The company engineered the RNA sequence to develop virus spike protein. These mRNA will then insert into the human body where it mimics and produces millions of copies of the spike protein. It results in the triggering of immune response and produces antibodies. If a vaccinated person later suffers from Coronavirus then those antibodies will be in a ready state to fight with the virus. The vaccine requires two doses four weeks apart.

As of now, there is no vaccine available in the market that is based on RNA mechanism.

How vaccine will stored

One of the bigger advantages of the Moderna vaccine over the Pfizer vaccine is how they can be stored. Moderna’s mRNA1273 can be kept at -20-degree centigrade while to store Pfizer’a vaccine it requires -75-degree centigrade. Since most laboratories and pharmacies are not designed to operate in such -75-degree centigrade, government agencies and pharma laboratories will need to create special laboratories to store Pfizer’s vaccine. On the other side, there is no such requirement for storing Moderna’s vaccine. As most deep freezers operate at -20-degree celsius.

The other advantage of mRNA1273 is that it can be kept in the refrigerator for 30-days but Pfizer’s vaccine can be last only for 5-days.